Application Notes

Research Presentations

Optimization of Chimeric Antigen Receptor (CAR) T Cell Design Guided by Sensitive Assessment of B Cell KillingAdoptive cellular therapy using chimeric antigen receptor (CAR) T cells has produced significant responses in patients with CD19+ hematological malignancies. Most clinical trials...Read More
Bispecific Antibody Constructs Mediate Immunotherapeutic Retargeting of Effector Cells Towards HBV Infected Target Cells

Dr. Felix Bohne
Institute of Virology, German Research Center for Environmental Health, Helmholtz Zentrum München

Chronic viral hepatitis is a major public health threat. Current strategies for eradicating the virus and treating virus-induced liver disease and hepatocellular carcinoma are very limited. Novel therapeutic strategies are in urgent need. Immunotherapeutic retargeting of effector cells is a promising approach to… Read More
Unraveling Kinase Inhibitor Cardiotoxicity with Cardiomyocyte Impedance Assays

Dr. Sarah K. Lamore
AstraZeneca Pharmaceuticals, Waltham, MA

Cardiovascular (CV) toxicity is a leading cause of drug failure. Though implementing earlier testing has successfully reduced hERG-related arrhythmias, additional assays capable of identifying other functional CV effects remain elusive. There is a pressing need to…Read More
Targeting the Reattachment of Circulating Breast Tumor Stem Cells to Reduce Metastasis

Dr. Stuart Martin
University of Maryland School of Medicine, Baltimore, MD

Breast tumor stem cells that are circulating in the bloodstream can invade distant tissues and lie dormant for long periods of time. Reemergence of these disseminated stem cells as metastatic tumors is a primary cause of patient death. In this webinar… Read More
Advances in Toxicity Bioassays – Unleashing the Power of Real-Time Cell Analysis for Health Risk Assessment

Dr. Stephan Gabos
University of Alberta, Edmonton, AB (Canada)

Modern public health protection requires ongoing surveillance of environmental media (water, air, food and soil) for potentially harmful chemicals. There is currently an unmet need for in vitro toxicity assays with higher sensitivity, lower interference, and better… Read More
A Novel in vitro Approach to Study Biocompatibility and Wound Healing

Dr. Sandra N. Garcia
Kinetic Concepts Inc., San Antonio, TX

Negative Pressure Wound Therapy (NPWT), where a vacuum is applied to an acute or chronic wound, has proven extremely effective for promoting would healing. The success of NPWT lies in its ability to draw the edges of a wound together, to promote granulation,…Read More


Using Impedance-Based Approaches for Measuring Antigen-Specific Cytotoxic T cell Activity

Dr. Keith L. Knutson
Mayo Clinic, Jacksonville, FL
The Vaccine & Gene Therapy Institute of Florida, Port Saint Lucie, FL

Immunotherapy, where the immune system is harnessed to treat and/or prevent disease, holds great promise in the fight against cancer. One noteworthy facet of cancer immunotherapy is the development of cancer-specific vaccines. In this webinar Dr. Keith L…Read More
Identifying Novel Combination Therapeutic Targets for Pancreatic Cancer

Dr. Melissa L. Fishel
Indiana University School of Medicine, Indianapolis, IN

Pancreatic cancer is presently a largely incurable disease. Increasing evidence suggests that effective treatment strategies will need to simultaneously target multiple molecular mediators of critical functions in pancreatic ductal adenocarcinoma cells (PDAC)…Read More
Cardiac Toxicity Assessment Using Stem Cell-Derived Cardiomyocytes

Dr. Matthew F. Peters
AstraZeneca Pharmaceuticals, Boston, MA

Cardiac toxicity is a major hurdle in drug development. In this webinar Dr. Matthew F. Peters of AstraZeneca Pharmaceuticals (Boston, MA) discusses the utility of combining ACEA Bioscience’s xCELLigence® Cardio system with stem cell-derived cardiomyocytes...Read More

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