Infectious Diseases: Using xCELLigence for Virology Studies

Tim Howell xCELLigence

Using xCELLigence for Virology Studies Virus infection of a host cell typically includes the selective suppression of host cell functions and redirection of resources towards viral replication and assembly, ultimately leading to host cell lysis.  While host cell rounding, detachment from the plate surface and/or lysis are readily detected by the xCELLigence® RTCA biosensors, more subtle changes in host cell …

Infectious Diseases

Tim Howell xCELLigence

Imagine being able to study pathogen fitness and behavior in real-time Now you can. By monitoring viral infections and bacterial biofilms continuously in an automated, non-invasive, and label-free manner the xCELLigence® Real-Time Cell Analysis (RTCA) instruments open up a whole new world of research possibilities. Learn more below: Key Applications Virology Bacterial Biofilms   Featured xCELLigence RTCA systems for infectious …

BIT’s International Drug Discovery Science and Technology | Japan | July 25-27, 2017

Jeff Li xCELLigence

ACEA Biosciences will be at BIT’s 15th Annual Congress of International Drug Discovery Science and Technology in Japan. We will be giving a talk during the Drug Discovery session on Wednesday, July 26 starting at 13:55. The xCELLigence Impedance Monitoring Instrument Enabling Label-Free Real-Time Assay in Drug Discovery and Development  Presented by Dr. Eiji Okubo Country Manager, APAC North and Japan, ACEA …

CYTO | June 10-14, 2017 | Boston, MA

Vivian Cao xCELLigence

Join ACEA Biosciences at CYTO 2017 in Boston. M.A., June 10 – 14. Stop by our booth #1081 and check out our poster presentation/technology seminar (lunch provided). More information below. Exhibitor Lunch Workshop Title: Combining Real-Time Cell Analysis With Flow Cytometry to Characterize BiTE/T Cell-Mediated Cytolysis and Neutrophil Extracellular Traps Date/Time: Monday June 12, 12:30-1:30 PM Location: Room 304 Presenters: …

Cancer & Immunotherapy Symposium hosted by ACEA Biosciences

ACEA Biosciences Event, Featured, xCELLigence

Register for the Cancer & Immunotherapy Symposium, April 15-16, immediately prior to the 2016 Annual AACR Meeting in New Orleans, Louisiana (USA). While traditional small molecule chemotherapy continues to play a critical role in cancer treatment, immunotherapy is rapidly gaining traction.  This Cancer and Immunotherapy symposium is the 4th annual cancer symposium hosted by ACEA.    This symposium is a forum to …

Cardiosafety: Drug-Induced Arrythmia

ACEA Biosciences xCELLigence

Between 1990 and 2006 one third of all safety-related drug withdrawals were due to cardiotoxicity, and cardiac liability continues to be a major hurdle in drug development.  Within the pharmaceutical industry, academic institutions, and regulatory agencies there are ongoing efforts to develop higher throughput and more predictive assays that can be used earlier in the drug discovery/development pipeline to minimize …

Cytotoxicity: Nanotoxicity

ACEA Biosciences xCELLigence

Nanomaterials are organic or inorganic particles whose size is less than 100 nanometers in at least one dimension.  Though nanomaterials hold tremendous promise for myriad applications, their impact on living cells in the short and long term are incompletely understood.  Numerous studies have suggested that nanomaterials, even when made of inert materials, can still display toxicity because of their physical …

Functional Analysis of Genes & Proteins: siRNA

ACEA Biosciences xCELLigence

Using the xCELLigence System for Target Identification and Validation (A) HeLa cells were transfected with various concentrations of KIF11 (the gene encoding Eg5) siRNA.  A time and concentration-dependent antimitotic time-dependent cell response profiles (TCRPs) was observed with higher siRNA concentrations producing more pronounced CI changes. The kinetics of the CI profiles is very similar between various concentrations of siRNAs: CI …

Cytotoxicity Overview

ACEA Biosciences xCELLigence

Cytotoxicity is the general quality of being toxic to cells, and can be caused by chemical stimuli, exposure to other cells (NK or T cells for example), or physical/environmental conditions (radiation exposure, temperature or pressure extremes, etc.).  Cytotoxic treatment can result in one of three potential cellular fates.  Whereas necrotic cell death involves the rapid loss of membrane integrity and …

Cell Migration/Invasion: Transmigration

ACEA Biosciences xCELLigence

See the Cell Migration/Invasion Overview for background information. The example below demonstrates the use of ACEA’s cell invasion and migration plate (CIM-Plate®) and the xCELLigence® RTCA DP system to study transmigration, with specific focus on cancer spheroid invasion. APPLICATION HIGHLIGHT: Studying Ovarian Cancer Spheroid Invasion of Mesothelial Cells Once ovarian cancer cells shed into the peritoneal fluid, they aggregate and …