Cardiac Disease Modeling

Human iPSC-Cardiomyocytes for Cardiac Disease Modeling

The pathophysiological cellular phenotypes of genetically heritable heart diseases can be modeled using disease-specific human induced pluripotent stem cell cardiomyocyte (hiPSC-CM) to gain broader understanding of the mechanisms leading to compromised electrical and contractile coupling.

Assessment of Disease Profiling

Genetically-engineered animal models have historically been used to model human diseases. However, there are valid concerns with the predictivity of these studies and translational potential to human conditions. Patient derived hiPSC-Cardiomyocytes provide an excellent model system to understand the underlying causes of these cardiomyopathies and can be potentially used for drug screening. The xCELLigence Cardio and CardioECR systems captures the integrated functional activity of cardiomyocytes for the assessment of cardiac disease models and for the screening of potential therapeutics to remedy the disease phenotype.

Figure 1: Beating rhythm analysis of monolayer CMs using the RTCA system. Irregular beating pattern was observed from the HCM iPSC-CMs. (Figure adapted from Cardiovascular Research (2014) 104, 258–269)

Overcome hurdles in your research to find your next insight of the mechanism of disease progression

Jason Maynes Video

Video: Induced PSCs for CV Disease Modeling and Precision Medicine

New Scientific Statement from the American Heart Association on hPSCs published in Circulation: Genomic and Precision Medicine.

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Jason Maynes Video

Video: Studying pediatric cardiac diseases in vitro using xCELLigence CardioECR system

Dr. Jason Maynes, analyzing contractility and ion channel activity of diseased pediatric iPSC-CMs using the CardioECR system.

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Publication: Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes as Models for Cardiac Channelopathies

This review aims to provide a basic understanding of the electrical activity of the heart and related channelopathies.

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Simplify your analysis – powerful software to help you elucidate information from data
Unique software monitors integrated ion channel activity, contractility, and longer term viability to elucidate adverse compound action.

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See What Real-Time Cell Analysis Does For You

The xCELLigence CardioECR® system combines real-time impedance monitoring with both multielectrode array (MEA) technology and a pacing function for the evaluation of cardiomyocyte function along with integrated ion channel activity.

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The xCELLigence® RTCA Cardio system uses non-invasive, label-free impedance monitoring to quantitatively evaluate cardiomyocyte health/function in real-time.

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Are your hiPSC-CMs displaying neonatal gene expression profile? Pacing hiPSC-CM under increasing pacing frequencies leading to functionally mature hiPSC-CM which display more adult-like gene expression profile.

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Training and Webinars

ACEA Biosciences offers webinars and free online training to help you find your next breakthrough

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ACEA Biosciences – The Cell Analysis Company

At ACEA Biosciences, our goal is to apply innovative technologies to the analysis of cellular mechanism and response, making studies possible that were not even imaginable just a few years ago. As a global company that places high value on collaborative interactions, rapid delivery of solutions, and providing the highest level of quality, we strive to meet our customers’ needs by delivering innovative, flexible, and scalable solutions to advance the next breakthrough in elucidating mechanisms of the human body. ACEA real-time cell analysis and flow cytometry technologies are fueling groundbreaking advancements in life science research and molecular diagnostics.