Human iPSC-Cardiomyocytes for Cardiac Disease Modeling
The pathophysiological cellular phenotypes of genetically heritable heart diseases can be modeled using disease-specific human induced pluripotent stem cell cardiomyocyte (hiPSC-CM) to gain broader understanding of the mechanisms leading to compromised electrical and contractile coupling.
Assessment of Disease Profiling
Genetically-engineered animal models have historically been used to model human diseases. However, there are valid concerns with the predictivity of these studies and translational potential to human conditions. Patient derived hiPSC-Cardiomyocytes provide an excellent model system to understand the underlying causes of these cardiomyopathies and can be potentially used for drug screening. The xCELLigence Cardio and CardioECR systems captures the integrated functional activity of cardiomyocytes for the assessment of cardiac disease models and for the screening of potential therapeutics to remedy the disease phenotype.
Figure 1: Beating rhythm analysis of monolayer CMs using the RTCA system. Irregular beating pattern was observed from the HCM iPSC-CMs. (Figure adapted from Cardiovascular Research (2014) 104, 258–269)
Simplify your analysis – powerful software to help you elucidate information from data
|Unique software monitors integrated ion channel activity, contractility, and longer term viability to elucidate adverse compound action.|
See What Real-Time Cell Analysis Does For You
The xCELLigence CardioECR® system combines real-time impedance monitoring with both multielectrode array (MEA) technology and a pacing function for the evaluation of cardiomyocyte function along with integrated ion channel activity.
|The xCELLigence® RTCA Cardio system uses non-invasive, label-free impedance monitoring to quantitatively evaluate cardiomyocyte health/function in real-time.|
Are your hiPSC-CMs displaying neonatal gene expression profile? Pacing hiPSC-CM under increasing pacing frequencies leading to functionally mature hiPSC-CM which display more adult-like gene expression profile.
ACEA Biosciences – The Cell Analysis Company
At ACEA Biosciences, our goal is to apply innovative technologies to the analysis of cellular mechanism and response, making studies possible that were not even imaginable just a few years ago. As a global company that places high value on collaborative interactions, rapid delivery of solutions, and providing the highest level of quality, we strive to meet our customers’ needs by delivering innovative, flexible, and scalable solutions to advance the next breakthrough in elucidating mechanisms of the human body. ACEA real-time cell analysis and flow cytometry technologies are fueling groundbreaking advancements in life science research and molecular diagnostics.