Join ACEA Biosciences at AAI IMMUNOLOGY 2017™ in Washington, D.C., May 12 – 16. Stop by our booth #801, check out our poster presentation and be sure to attend our lunch workshop.
IMMUNOLOGY 2017™ is one of the largest annual gathering of immunologists worldwide. Attendees hear from global leaders in immunology and talented early-career investigators alike – all discussing breakthroughs across the full spectrum of topics in the field.
Exhibitor Lunch Workshop
Join ACEA Biosciences, Inc. for lunch while learning about the capabilities of the NovoCyte flow cytometer in the following ACEA-sponsored talk:
Title: Exosomes Present in Human Ovarian Tumor Microenvironments Rapidly Arrest T Cells
Date/Time: Saturday May 13, 12:30-1:15 PM
Location: Exhibitor Workshop 2
Presenter: Paul K. Wallace, Ph.D.
Director of the Flow and Image Cytometry Department at the Roswell Park Cancer Institute, Buffalo, NY
Dr. Paul Wallace of Roswell Park Research Institute presented at the ACEA Biosciences Workshop during the 2017 Immunology Conference in Washington DC, his study on Exosomes Present in Human Ovarian Tumor Microenvironment Rapidly Arrest T Cells.
In this workshop Dr. Wallace presented how membrane bound extracellular vesicles isolated from ovarian cancer patients have biophysical and compositional characteristics similar to vesicles called exosomes. The tumor-associated exosomes inhibit an early activation endpoint of a significant portion of virus (EBV and CMV) specific CD8+ T-cells that are stimulated with viral peptides presented in the context of Class I MHC. Early and late activation endpoints of peripheral blood CD4+ and CD8+ T-cells stimulated with immobilized antibodies to CD3 and CD28 are also significantly inhibited by the exosomes. The inhibition of the T-cells is induced directly and rapidly and occurs coincidentally with the exosomes binding to and internalization by the T-cells. The early arrest in the activation occurs without a loss of viability in the T-cells. The immune suppressive exosomes in the tumor microenvironment and the ability to block their T-cell inhibitory activity represent a potential therapeutic target to enhance the anti-tumor immunity of quiescent tumor-associated T cells, and to prevent the functional arrest of endogenous or adoptively transferred T-cells upon their entry into the tumor.
Title: Combining impedance-based viability measurements and flow cytometric analytic quantitation to evaluate effector cell killing of T lymphocytes
Date/Time: Monday, May 15, 2:30 PM – 3:45 PM
Location: Exhibit/Poster Hall
Session: Immune Responses in Tumor Therapy