Employing noninvasive gold microelectrodes in diverse multiwell plate formats, our xCELLigence Real-Time Cell Analysis (RTCA) systems maximize the physiological relevance of data extracted from in vitro cellular assays by enabling label-free, real-time monitoring of cell proliferation, cell size/morphology, cell attachment quality, and cell invasion/migration. By continuously providing this data in the short (minutes to hours) and long (days to weeks) time regimes, RTCA provides a phenotypic view of cellular behavior at an unprecedented level of detail.
Wireless data transfer & large surface area wells. This instrument transmits data wirelessly from a standard CO2 cell culture incubator to the Control Unit (an iPad housed outside the incubator). The larger well size of the plates used by this model provides enough cells for complementary assays including western blotting, sequencing analyses, FACS, imaging, etc.
Cell invasion and migration. Capable of analyzing cell number, size/morphology, and attachment quality, with the added ability of making kinetic measurements of cell invasion and migration using an electronically integrated Boyden chamber.
96-well format. The SP (single plate) model differs from our other xCELLigence instruments in that it uses a single 96-well electronic microtiter plate.
6 x 96-well format. This instrument can host up to six 96-well electronic microtiter plates for a total capacity of 576 wells. These six plates can be controlled and monitored simultaneously yet independently of one another, allowing maximal productivity for multiple users.
384-well high throughput screening. Up to four 384-well instruments can be integrated and controlled by a single analyzer/control unit, giving a total of 1536 wells. Configured for high-throughput screening applications, the RTCA HT model can be used either as a standalone instrument, or integrated into a high-throughput workflow using a liquid handler for fully automated screening.
Cardiomyocyte contractility and viability measured in real-time. The xCELLigence® RTCA Cardio instrument expands upon ACEA’s microelectronic-based cellular assay systems to enable monitoring of cardiomyocyte beating for cardiotoxicity assessment.
Cardiomyocyte contractility, viability, and electrical activity measured in real-time. The new xCELLigence® RTCA CardioECR instrument combines high frequency measurement of cell-induced electrical impedance with multielectrode array technology to simultaneously assess cardiomyocyte contractility, viability, and electrophysiology.