The use of the xCELLigence System, developed by ACEA Biosciences, Inc. and its worldwide cooperation partner Roche, in a label-free measurement of natural killer (NK) cell cytotoxic activity in real time was recently profiled in the Forbes.com Business Wire.  The article, published on June 26, 2008, details the use of the xCELLigence System in the label free, real time assay of NK mediated cytolysis.  As noted in the article, the xCELLigence System  is the only system available today that permits the real time monitoring of NK cell mediated cytolysis without labeling either the target cells or the NK cell themselves, or using any chemical reporters in the assay.  This provides the user with a much more accurate assessment of cytolytic activity.  Current assays rely heavily on labels and reporters, often radioactive, are labor intensive, and typically have high backgrounds due to the leakage of the radioactive label from the target cells.  The xCELLigence System offers the user a label free alternative for research in the important area of NK cell-mediated cytotoxicity with significant benefits in ease of use and improved data quality.

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About ACEA

ACEA Biosciences has pioneered the development of high-performance microelectronic systems for cell-based assays. ACEA and its partner Roche will market on a world-wide basis ACEA’s microplate-based biosensor platform for a variety of applications in drug development, toxicology, cancer research, and medical microbiology and virology. ACEA's products are designed to meet the increasing needs of the life science research and drug discovery markets by providing cost-effective, high content, real time detection systems that simplify complex cell-based assay procedures and increase productivity. With its international reach, ACEA Biosciences works closely with scientists throughout the world. Hangzhou, China is the site of ACEA's world-class manufacturing operations. ACEA Biosciences headquarters is in San Diego, USA.